Any drug will cumulate in the body if amount of administration is much more than the rate of elimination. However, bit by bit eradicated drugs are particularly liable to result in cumulative toxicity, e.g. prolonged use of chloroquine results in retinal injury.Drug metabolism can affect the plasma concentrations of drugs, which have to be viewed as
LC–MS (Liquid chromatography–mass spectrometry) is a method that merges the physical separation of HPLC With all the impressive mass analysis capabilities of MS.is really a stationary medium, which may be a stagnant bulk liquid, a liquid layer around the reliable period, or an interfacial layer involving liquid and good. In HPLC, the stationary
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